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To provide a quantitative and qualitative synthesis of the available evidence on the role of Hypothalamic-Pituitary-Adrenal (HPA) axis in the pathophysiology of Bipolar Disorder (BD). Caspases have been implicated in the induction of apoptosis in most systems studied. We describe how metabolic networks can be represented using stoichiometric matrices and well-defined constraints on metabolic fluxes. Persistent non-progressing edemas of distal parts of extremities developed after bone fractures in the lower part of the shin were studied in 12 patients.

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